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98% Pure Echinocystic Acid: High-Purity Triterpenoid for Advanced Anti-Inflammatory & Cancer Research
Echinocystic Acid is a bioactive triterpenoid compound (molecular formula: C??H??O?, MW: 472.71), rigorously purified to ≥98% via HPLC analysis. Sourced from natural botanical extracts, this high-grade standard is essential for precision-driven research in pharmacology and molecular biology.
Product Name :
Echinocystic AcidCAS No. :
510-30-5Appearance :
White to off-white crystalline powderSpecification :
98%CAS: 510-30-5
Molecular Formula: C??H??O?
Molecular Weight: 470.68 g/mol
Appearance: White to off-white crystalline powder
Dual-Target Anti-Inflammatory & Anti-Fibrotic Agent
≥98% Purity (HPLC-ELSD validated)
Joint Health: Inhibits IL-1β-induced MMP-13 by 89% (IC??: 3.8 μM) in chondrocytes.
Liver Protection: Reduces CCl?-induced fibrosis by 71% at 20 mg/kg/day via TGF-β/Smad3 blockade.
1. Anti-Arthritic Activity
Cartilage Protection: 10 μM downregulates ADAMTS-5 (↓78%) and preserves collagen II in OA models.
Synovitis Relief: 5 mg/kg intra-articular injection reduces TNF-α by 64% in RA rats.
2. Hepatorenal Anti-Fibrosis
Liver Fibrosis: Suppresses α-SMA expression (↓82%) and hydroxyproline (↓69%) at 15 mg/kg.
Renal Protection: Attenuates UUO-induced tubulointerstitial fibrosis via Nrf2/HO-1 activation.
3. Metabolic Regulation
Diabetes Complication Control: 50 mg/kg/day decreases AGEs formation (↓57%) and podocyte apoptosis.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD, C18 column) |
| Source | Echinocystis lobata roots (wildcrafted, Altai Mountains) |
| Melting Point | 298-301°C (dec.) |
| Solubility | DMSO (25 mg/mL), ethanol (15 mg/mL); insoluble in H?O |
| Storage | 2-8°C in desiccated containers (36-month stability) |
| Key Impurities | Oleanolic acid ≤0.5% (HPLC-controlled) |
| Certifications | ISO 9001, SGS heavy metals report |
Pharmaceutical Development
OA Therapeutics: 10-50 mg injectable formulations for cartilage regeneration (preclinical).
Hepatoprotectants: Synergizes with silymarin (1:2 ratio) in NAFLD models (ALT ↓52%).
Nutraceutical Formulations
Joint Health Capsules: 100 mg doses in chondroitin complexes (WOMAC score ↓41% in trials).
Liver Detox Blends: 5% inclusion in milk thistle extracts for glutathione synthesis boost.
Cosmeceutical Innovations
0.1-0.5% creams inhibit elastase (IC??: 8.7 μM) and UV-induced collagen degradation.
1. Eco-Extraction Technology
CO? Supercritical Extraction:
Purity: 95.3% initial yield
Zero organic solvent residues
Energy consumption reduced 35% vs. ethanol reflux
2. Crystallization Precision
Acetone-Water Recrystallization:
Columnar crystals (200-500 μm length)
Residual acetone <500 ppm (ICH Q3C)
3. Global Compliance
Ready dossiers for:
US FDA Dietary Ingredient Safety
EU Novel Food Application
Japan JHFA Certification
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 1 g | Amber glass vial + desiccant | 24 months |
| 10 g | Double aluminum foil bag | 24 months |
| 100 g | Pharma HDPE jar + nitrogen | 24 months |
| 500 g | Vacuum-sealed steel can | 24 months* |
*At 2-8°C, RH <30%; ICH Q1A(R2) stability verified
Q: How to validate MMP-13 inhibition?
A: Batch-specific IL-1β-stimulated chondrocyte assay reports included.
Q: Solubility for in vivo studies?
A: Use PEG-400/water (1:1) for 5 mg/mL solubility (s.c./i.p. administration).
Q: Stability in enteric-coated tablets?
A: Compatible with HPMC-AS; maintains >95% potency after 24mo at 25°C/60% RH.
Toxicity: LD?? (oral, rat) >2000 mg/kg; AMES test negative.
Allergen Status: Gluten-free, non-GMO documentation available.
Heavy Metals: As <1ppm, Pb <0.5ppm (ICP-MS report per USP <232>).
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