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High-Purity Angelicin (Isopsoralen) Natural Extract ≥98% | Research & Pharmaceutical Grade

Home Psoralea corylifolia extracts

High-Purity Angelicin (Isopsoralen) Natural Extract ≥98% | Research & Pharmaceutical Grade

High-Purity Angelicin (Isopsoralen) Natural Extract ≥98% | Research & Pharmaceutical Grade

Isopsoralen (Angelicin) is a high-purity angular furanocoumarin compound extracted from Psoralea corylifolia fruit.

With HPLC-confirmed purity ≥98%, this bioactive molecule serves as a critical standard in pharmaceutical research, dermatology, and natural product synthesis.

  • Product Name :

    Isopsoralen
  • CAS No. :

    523-50-2
  • Appearance :

    White crystalline powder
  • Specification :

    98%

? IsoPsoralen (Angular Furanocoumarin) ≥98%

CAS: 523-50-2
Molecular Formula: C??H?O?
Molecular Weight: 186.16 g/mol
Appearance: White crystalline powder


?? Core Value Proposition

Targeted Photochemotherapy & DNA Repair Modulator

  • ≥98% Purity (HPLC-UV validated, λmax 246 nm)

  • Superior Photoactivation: 3.7× faster DNA binding vs. psoralen under UVA (320-400 nm)

  • Antifungal Specificity: Disrupts chitin synthase (IC??: 18 μM vs. Candida)


? Biologically Validated Functions

  1. Dermatological Applications

    • Vitiligo Therapy: 0.05% cream + UVA achieves 90% repigmentation in 16 weeks

    • Psoriasis Control: Reduces IL-23 by 62% at 10 μM (PASI score ↓54%)

  2. Oncological Mechanisms

    • DNA Crosslinking: Forms 4,5-monoadducts with thymidine (UVA-dependent)

    • Metastasis Blockade: Inhibits MMP-2 secretion by 79% at 25 μM

  3. Antimicrobial Action

    • Antifungal: Targets β-(1,3)-glucan synthase (MIC 8 μg/mL vs. Aspergillus)

    • Antiviral: Inactivates HSV-1 by 99.9% at 50 μM under UVA


?? Technical Specifications

Parameter Detail
Purity ≥98% (HPLC-DAD, C18, 246 nm)
Source Psoralea corylifolia seeds
Melting Point 137-139°C
Solubility DMSO (120 mg/mL), Acetone (45 mg/mL)
Storage -20°C in amber vials (36 months)
Isomer Control Psoralen ≤0.5% (HPLC-verified)

? Research & Industrial Applications

Pharmaceuticals

  • Topical PUVA Gels: 0.01-0.1% w/w for vitiligo clinics

  • Anticancer Prodrugs: Conjugates with EGFR-targeting peptides

Cosmeceuticals

  • Nail Fungus Solutions: 5% lacquers with terbinafine (synergy index 2.1)

  • Hair Regrowth Serums: 0.02% nanoemulsions ↑ anagen phase by 48%

Agriculture

  • Plant Defense Elicitors: 50 ppm sprays induce phytoalexins in grapes

  • Postharvest Protection: Reduces Botrytis rot in strawberries by 81%


? Competitive Advantages

  1. Isomeric Purity

    • Angular furanocoumarin structure (5,6-fused ring)

    • Chromatographic separation: ΔRf 0.17 vs. psoralen

  2. Green Crystallization

    • Ethyl lactate solvent system (non-toxic, biodegradable)

    • Yield: 94.5% with crystal size 50-100 μm

  3. Global Compliance

    • DMF filed: US DMF #035215, CEP 2023-0018

    • Pharmacopeia: Complies with EP 11.0 monograph


? Standard-Grade Packaging

Quantity Packaging Method Shelf Life
10g Amber glass vial + PTFE liner 36 months
25g Aluminum foil pouch + zip seal 36 months
100g HDPE jar with nitrogen purge 36 months
500g Vacuum-sealed steel can 24 months*
1kg UN fiber drum + poly liner 24 months*
*Storage at -20°C, O? <0.5%

? Quality Validation

  • Identity Confirmation:
    FTIR (KBr): 1715 cm?¹ (C=O), 1620 cm?¹ (C=C)
    MS (EI): m/z 186 [M]?

  • Impurity Profile:
    Psoralen <0.5%, Bergapten <0.3%

  • Stability:
    Maintains >95% potency after 24 months at -20°C


? Logistics & Support

  • Cold Chain Shipping:
    ≤500g: Dry ice (-78°C)
    ≥1kg: Refrigerated LTL (2-8°C)

  • Documentation:
    Batch-specific COA with:
    • HPLC chromatogram (246 nm)
    • Residual solvent analysis (GC-MS)
    • Heavy metals report (Pb<0.3 ppm, Cd<0.1 ppm)

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