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Cyclopamine ≥98% | CAS: 4449-51-8 | Targeted Hedgehog Pathway Inhibitor
Cyclopamine 98% (CAS: 4449-51-8), a potent steroidal alkaloid targeting the Hedgehog pathway, selectively inhibits Smoothened (Smo) with IC50 of 46 nM. This pharma-grade inhibitor is validated for oncology research (pancreatic/basal cell carcinoma) and stem cell differentiation studies.
Product Name :
CyclopamineCAS No. :
4449-51-8Appearance :
Fine white powderSpecification :
98%Molecular Formula: C??H??NO?
Molecular Weight: 411.62
Appearance: White crystalline powder
? Pharma-Grade Purity & Bioactivity
Exclusively ≥98% Pure: Rigorously verified by HPLC, NMR & MS (Lot-specific COA)
Bioactivity Guaranteed: Confirmed Smo inhibition (IC??: 46–280 nM) with batch-specific cell-based assay reports
? Clinically Validated Benefits
Suppresses Tumor Growth: Targets Hedgehog pathway in pancreatic/liver cancers (IC??: 46 nM)
Blocks Metastasis: Reduces cancer cell migration by 500-fold in Hedgehog-dependent models
Induces Apoptosis: Overcomes chemo-resistance in aggressive cell lines (e.g., L3.6sl)
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD) |
| Identification | NMR, Mass Spectrometry |
| Storage | -20°C Dark, sealed, inert atmosphere |
| Shelf Life | 24 months* |
| Solubility | DMSO (10 mM), ethanol, methanol |
| Packaging | 20mg–10kg (vacuum-sealed), 25kg GMP drums |
? Oncology Research
Chemo-adjuvant for pancreatic/bile duct cancers
Hedgehog target validation (glioblastoma, basal cell carcinoma)
? Stem Cell Research
Shh signaling modulation in regenerative medicine
| Advantage | Detail |
|---|---|
| Bioactivity Proof | Lot-specific Smo binding assays included |
| Ethical Sourcing | Traceable Veratrum californicum (Changbai Mountain) |
| Global Compliance | ISO 9001/Kosher, USP/EP heavy metals ≤10ppm |
| Weight | Packing Method | Transport |
|---|---|---|
| 20mg–1kg | Glass vials + dry ice | DHL/FedEx (3–7d) |
| 1kg–25kg | Sealed buckets (-20°C) | By Air (5–10d) |
| >25kg | GMP drums with temp loggers | By Sea (15–45d) |
Q: How to verify bioactivity?
→ Free 20mg samples with COA + cell assay data provided.
Q: Can I get water-soluble forms?
→ Cyclodextrin-complexed analogs available (OEM inquiry).
Q: Stability during shipping?
→ All shipments use dry ice/-20°C protocols with temp loggers.
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