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Pharma-Grade Wogonin (632-85-9), a yellow crystalline flavonoid, excels in solubility (methanol/ethanol/acetone) and stability (storage: 2–8°C, inert atmosphere) . Validated for antioxidant, diuretic, and immunomodulatory applications, it suppresses lipid peroxidation and collagen-induced platelet activation
Product Name :
WogoninCAS No. :
632-85-9Appearance :
Yellow crystalline powderSpecification :
98%Molecular Formula: C??H??O? | Molecular Weight: 284.26
Appearance: Yellow crystalline powder
Source: Roots of Scutellaria baicalensis (Chinese Skullcap）
? Pharma-Grade Purity & Bioactivity
Exclusively ≥98% Pure: Rigorously verified by HPLC, NMR, and MS (Lot-specific COA provided).
Bioactivity Guaranteed: Confirmed inhibition of CDK9, NF-κB, and PI3K/Akt pathways with anti-inflammatory and anti-tumor efficacy (IC?? values documented in cell-based assays).
? Clinically Validated Benefits
Suppresses Tumor Growth: Inhibits angiogenesis and metastasis by blocking PI3K/Akt/NF-κB signaling (e.g., in breast cancer and leukemia models).
Anti-Inflammatory Action: Reduces LPS-induced vascular permeability and cytokine production (e.g., PGE?, NO) via Src-ERK1/2-NFκB pathway modulation.
Overcomes Drug Resistance: Reverses multidrug resistance in myeloid leukemia by downregulating MRP1 via Nrf2/ARE pathway inhibition.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD) |
| Identification | NMR, Mass Spectrometry |
| Storage | 2–8°C, dark, sealed, inert atmosphere |
| Shelf Life | 24 months* |
| Solubility | DMSO (10 mM), ethanol, methanol; insoluble in water |
| Packaging | 20mg–25kg (vacuum-sealed vials or GMP drums) |
? Oncology & Pharmacology
Chemo-adjuvant: Enhances efficacy in pancreatic, breast, and leukemia therapies by sensitizing drug-resistant cells.
Metastasis Inhibition: Reduces cancer cell migration by blocking MLCK/MLC pathways and vascular remodeling.
? Anti-Inflammatory Therapeutics
Allergy & Asthma Management: Attenuates eosinophil-driven inflammation and airway hyperreactivity via caspase-3 activation.
Neuroprotection: Modulates microglial activation (e.g., BV-2 cells) to mitigate neuroinflammation.
| Advantage | Detail |
|---|---|
| Bioactivity Proof | Lot-specific assay data (CDK9 inhibition, NF-κB suppression) included |
| Ethical Sourcing | Traceable to Scutellaria baicalensis (cultivated in China) |
| Global Compliance | ISO 9001, heavy metals ≤10ppm (USP/EP standards) |
| Weight | Packing Method | Transport |
|---|---|---|
| 20mg–1kg | Amber glass vials + desiccant | DHL/FedEx (3–7 days) |
| 1kg–25kg | Sealed buckets with temp loggers | By Air (5–10 days) |
| >25kg | GMP drums (-20°C monitored) | By Sea (15–45 days) |
Q: How to verify anti-tumor activity?
→ Free 20mg samples with COA + in vitro assay data (e.g., NF-κB inhibition) provided.
Q: Solubility limitations for in vivo studies?
→ Water-soluble cyclodextrin-complexed analogs available (OEM inquiry).
Q: Stability during transit?
→ All shipments use 2–8°C protocols with temperature loggers; resealable packaging prevents oxidation.
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Pharma-Grade Wogonin (632-85-9), a yellow crystalline flavonoid, excels in solubility (methanol/ethanol/acetone) and stability (storage: 2–8°C, inert atmosphere) . Validated for antioxidant, diuretic, and immunomodulatory applications, it suppresses lipid peroxidation and collagen-induced platelet activation
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