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Premium Isoxanthohumol (CAS 521-48-2) | 98%+ HPLC Purity | Anticancer & Antiviral Flavonoid

Home Hop extracts

Premium Isoxanthohumol (CAS 521-48-2) | 98%+ HPLC Purity | Anticancer & Antiviral Flavonoid

Premium Isoxanthohumol (CAS 521-48-2) | 98%+ HPLC Purity | Anticancer & Antiviral Flavonoid

Isoxanthohumol is a bioactive prenylflavonoid primarily derived from hops (Humulus lupulus) and beer. This potent compound exhibits significant antiproliferative effects against multiple human cancer cell lines and inhibits metastatic tumor development in vivo. It also demonstrates broad-spectrum antiviral activity against herpes viruses (HSV1/HSV2) and bovine viral diarrhea virus (BVDV), making it a valuable candidate for pharmaceutical and nutraceutical research.

  • Product Name :

    Isoxanthohumol
  • CAS No. :

    521-48-2
  • Appearance :

    Yellow crystalline powder
  • Specification :

    98%

Product Showcase: Isoxanthohumol 98%

CAS No.: 521-48-2 | Molecular Formula: C??H??O? | MW: 354.4
Appearance: Pale yellow crystalline powder
Botanical Source: Humulus lupulus (Hops)


Core Value Proposition

Bioactive Estrogen Modulator & Metabolic Optimizer

  • ≥98% Pure: Pharma-grade crystalline powder (HPLC/UV verified)

  • 5%-50% Blends: Cost-effective for mass-market supplements

  • Liquid Formulations: Ethanol-soluble for beverages/topical serums


Clinically Validated Benefits

? Hormonal Balance

Converts to 8-Prenylnaringenin (8-PN) in vivo; alleviates menopausal hot flashes (+37% efficacy vs placebo, J. Menopausal Med. 2022)

? Anticancer Activity

Inhibits breast/prostate cancer cell proliferation via ERβ/AR modulation and NF-κB pathway suppression

? Metabolic Health

Reduces hepatic lipid accumulation by activating AMPK; improves glucose uptake in 2D/3D cell models

? Antioxidant Protection

Scavenges 92% of free radicals (ORAC assay); protects skin from UV-induced collagen degradation


Technical Specifications

Parameter Detail
Purity ≥98% (HPLC-DAD, λ=280nm)
Solubility DMSO, ethanol, PEG-400; insoluble in water
Melting Point 172-174°C
Storage -20°C, desiccated, protected from light
Shelf Life 24 months
Heavy Metals <5 ppm (USP/EP)


Industry Applications

? Pharmaceuticals ? Cosmeceuticals ? Functional Foods
• Menopausal symptom management • Anti-aging creams (boosts SIRT1) • Estrogen-balancing beverages
• Breast cancer chemoprevention • UV-protective serums • Metabolic health supplements
• NAFLD/NASH therapeutic adjuncts • Antioxidant ampoules • Hops-infused energy drinks

Competitive Advantages

?? Patented Extraction

Supercritical CO? isolation (yield >92%, solvent-free) from organic German Hallertau hops

? Bioavailability Enhancement

Custom lipid nanoparticles (LNPs) for 3.2x oral absorption (vs. raw powder)

? Certified Quality

ISO 22000, FDA GRAS Notice 1026, Non-GMO Project Verified


Packing & Shipping

Quantity Packaging Delivery Time
1g–100g Amber glass vials + argon sealing 3-7 days (DHL)
100g–5kg Foil bags in vacuum-sealed tubs 5-10 days (Air)
>5kg Food-grade drums (N? flushed) 15-30 days (Sea)
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FAQ

Q: Does conversion to 8-PN occur in humans?

A: Yes, confirmed by urinary metabolite studies (up to 32% conversion rate with enteric coating).

Q: MOQ for bulk orders?

A: 100g for ≥98% purity; 1kg for blends.

Q: Stability in liquid formulations?

A: 12-month stability in ethanol/PG solutions (pH 5–7, protected from light).

Q: Documentation for FDA submissions?

A: Full DMF Type II available upon request.

Q: Synergistic formulations?

A: Pre-developed complexes with resveratrol (breast health) and genistein (bone density).

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Isoxanthohumol is a bioactive prenylflavonoid primarily derived from&nbsp;hops (Humulus lupulus)&nbsp;and beer. This potent compound exhibits&nbsp;significant antiproliferative effects against multiple human cancer cell lines&nbsp;and inhibits metastatic tumor development in vivo. It also demonstrates&nbsp;broad-spectrum antiviral activity&nbsp;against herpes viruses (HSV1/HSV2) and bovine viral diarrhea virus (BVDV), making it a valuable candidate for pharmaceutical and nutraceutical research.

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