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Discover 98% Phloretin from Apples: A New Generation of Cosmetic and Medicinal Ingredient
Phloretin, with a purity of 98%, is a high - quality plant extract derived from the peels and root barks of apples.It has extremely strong antioxidant properties. It can inhibit the disordered proliferation of cells and serves as an anti - mutagenic factor in food. It shows potential as a chemotherapy drug and can be used in the treatment of skin cancer and other tumors.
Product Name :
PhloretinCAS No. :
60-82-2Appearance :
Off-white to pale yellow crystalline powderSpecification :
98%CAS: 60-82-2
Molecular Formula: C??H??O?
Molecular Weight: 274.27 g/mol
Appearance: Off-white to pale yellow crystalline powder
Dual-Action Skin Whitening & Glucose Blocker
≥98% Purity (HPLC-PDA/MS validated, λmax 285 nm)
Tyrosinase Inhibitor: Blocks melanin synthesis (IC??: 8.3 μM) via competitive inhibition.
SGLT1 Antagonist: Reduces intestinal glucose absorption by 74% at 50 μM.
1. Dermatological Applications
Hyperpigmentation Control: 1% cream decreases melanin index by 42% in UV-induced models.
Collagen Protection: Inhibits MMP-1 (82%) and MMP-9 (76%) at 10 μM.
2. Metabolic Health
Postprandial Glucose: 250 mg oral dose lowers glucose AUC by 28% in humans.
Insulin Sensitivity: Upregulates GLUT4 translocation (3.1×) in skeletal muscle.
3. Antioxidant Activity
ROS Scavenging: EC?? 4.8 μM (superoxide), 5.2 μM (hydroxyl radical).
DNA Protection: Reduces UV-induced 8-OHdG by 65% at 20 μM.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18 column) |
| Source | Malus domestica peel (organic, EU origin) |
| Melting Point | 261-263°C |
| Solubility | DMSO (150 mg/mL), ethanol (50 mg/mL); insoluble in H?O |
| Storage | 2-8°C in opaque containers (48-month stability) |
| Key Impurities | Phlorizin ≤0.5% (HPLC-controlled) |
| Certifications | ISO 9001, COSMOS Organic Approved |
Cosmeceutical Formulations
Whitening Serums: 0.5-2.0% concentrations (superior to kojic acid in clinical trials).
Anti-Aging Creams: 1% nanoemulsions reduce wrinkle depth by 38% in 12-week study.
Nutraceutical Products
Glucose Control Capsules: 200-400 mg doses with berberine (synergy index 1.8).
Sports Nutrition: 50 mg/serving in pre-workout for glycogen sparing.
Functional Foods
Beverage Stabilization: β-cyclodextrin complexes (0.1%) extend shelf-life 2.5×.
1. Green Extraction Technology
Enzyme-Assisted Extraction:
Pectinase/cellulase pretreatment → Ethanol extraction
Yield: 94.2% purity
Solvent reduction: 50% vs. conventional
2. Polymorph Control
Needle Crystals (α-form):
Length: 50-150 μm
Bulk density: 0.52 g/cm³
Flowability: Carr index 15
3. Global Compliance
Dossiers ready for:
EU Cosmetics Regulation (EC) No 1223/2009
FDA OTC Monograph M020
China NMPA Cosmetic Ingredient Registration
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 500 g | Double aluminum foil bag + desiccant | 24 months |
| 1 kg | Pharma HDPE jar + nitrogen24 | months |
| 5 kg | Vacuum-sealed steel can | 24months* |
| 10 kg | Nitrogen-flushed fiber drum | 24 months* |
| 25 kg | UN-certified composite drum | 24 months* |
*At 2-8°C, RH <40%; ICH Q1A(R2) validated
Q: How to validate tyrosinase inhibition?
A: Batch-specific mushroom tyrosinase assay reports (IC??) included.
Q: Solubility for cosmetic emulsions?
A: Use PEG-8 caprate (solubility ↑ to 120 mg/mL) or nanoliposomes.
Q: Photostability in creams?
A: Maintains >95% potency with 0.05% tocopherol + 1% octinoxate.
Toxicity: LD?? (dermal, rabbit) >2000 mg/kg; non-irritating (OECD 439).
Allergen Status: Vegan, gluten-free, non-GMO certified.
Heavy Metals: As <0.1 ppm, Pb <0.2 ppm (ICP-MS per ISO 17294).
*Data sources: Int. J. Cosmet. Sci. 2021; 43(4): 411-425; J. Funct. Foods 2022; 88: 104890.*
| Weight | Packing Method | Delivery | Time |
|---|---|---|---|
| <5 kg | Foil bags in insulated cartons | DHL/FedEx | 3-7 days |
| 5-25 kg | Sealed HDPE drums | Air Freight | 5-10 days |
| >25 kg | UN fiber drums + palletized | Sea Freight | 15-45 days |
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